DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.

@article{Bergink2006DNADT,
  title={DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.},
  author={Steven Bergink and Florian A. Salomons and Deborah Hoogstraten and Tom A. M. Groothuis and Harm de Waard and Junxin Wu and Li Yuan and Elisabetta Citterio and Adriaan B. Houtsmuller and Jacques Neefjes and Jan H. J. Hoeijmakers and Wim Vermeulen and Nico P Dantuma},
  journal={Genes & development},
  year={2006},
  volume={20 10},
  pages={1343-52}
}
Chromatin changes within the context of DNA repair remain largely obscure. Here we show that DNA damage induces monoubiquitylation of histone H2A in the vicinity of DNA lesions. Ultraviolet (UV)-induced monoubiquitylation of H2A is dependent on functional nucleotide excision repair and occurs after incision of the damaged strand. The ubiquitin ligase Ring2 is required for the DNA damage-induced H2A ubiquitylation. UV-induced ubiquitylation of H2A is dependent on the DNA damage signaling kinase… CONTINUE READING