DNA damage to a single chromosome end delays anaphase onset.

@article{Silva2014DNADT,
  title={DNA damage to a single chromosome end delays anaphase onset.},
  author={B{\'a}rbara Alcaraz Silva and Jessica R. Stambaugh and Kyoko Yokomori and Jagesh V. Shah and Michael W. Berns},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 33},
  pages={
          22771-84
        }
}
Chromosome ends contain nucleoprotein structures known as telomeres. Damage to chromosome ends during interphase elicits a DNA damage response (DDR) resulting in cell cycle arrest. However, little is known regarding the signaling from damaged chromosome ends (designated here as "TIPs") during mitosis. In the present study, we investigated the consequences of DNA damage induced at a single TIP in mitosis. We used laser microirradiation to damage mitotic TIPs or chromosome arms (non-TIPs) in PtK2… CONTINUE READING
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