DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis

@inproceedings{Zeman2014DNADD,
  title={DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis},
  author={Michelle K. Zeman and Jia-Ren Lin and Raimundo Freire and Karlene A Cimprich},
  booktitle={The Journal of cell biology},
  year={2014}
}
Deoxyribonucleic acid (DNA) lesions encountered during replication are often bypassed using DNA damage tolerance (DDT) pathways to avoid prolonged fork stalling and allow for completion of DNA replication. Rad18 is a central E3 ubiquitin ligase in DDT, which exists in a monoubiquitinated (Rad18•Ub) and nonubiquitinated form in human cells. We find that Rad18 is deubiquitinated when cells are treated with methyl methanesulfonate or hydrogen peroxide. The ubiquitinated form of Rad18 does not… CONTINUE READING

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