DNA damage signaling triggers the cytoplasm-to-vacuole pathway of autophagy to regulate cell cycle progression.

@article{Eapen2013DNADS,
  title={DNA damage signaling triggers the cytoplasm-to-vacuole pathway of autophagy to regulate cell cycle progression.},
  author={Vinay V. Eapen and James E Haber},
  journal={Autophagy},
  year={2013},
  volume={9 3},
  pages={440-1}
}
Budding yeast cells suffering a single unrepaired DNA double-strand break (DSB) trigger the ATR (Mec1)-dependent DNA damage checkpoint and arrest prior to anaphase for 12-15 h, following which they adapt and resume cell division. When the DNA lesion can be repaired, the checkpoint is extinguished and cells "recover" and resume mitosis. In this autophagic punctum, we report that hyperactivation of autophagy-specifically via the cytoplasm-to-vacuole targeting (Cvt) pathway-prevents both… CONTINUE READING