DNA damage signaling in response to double-strand breaks during mitosis

@inproceedings{Giunta2010DNADS,
  title={DNA damage signaling in response to double-strand breaks during mitosis},
  author={Simona Giunta and Rimma Belotserkovskaya and Stephen P. Jackson},
  booktitle={The Journal of cell biology},
  year={2010}
}
The signaling cascade initiated in response to DNA double-strand breaks (DSBs) has been extensively investigated in interphase cells. Here, we show that mitotic cells treated with DSB-inducing agents activate a "primary" DNA damage response (DDR) comprised of early signaling events, including activation of the protein kinases ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PK), histone H2AX phosphorylation together with recruitment of mediator of DNA damage checkpoint… CONTINUE READING
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