DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation.

@article{Moiseeva2006DNADS,
  title={DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation.},
  author={Olga Moiseeva and Fr{\'e}d{\'e}rick A Mallette and Utpal K. Mukhopadhyay and Adrian Moores and Gerardo Ferbeyre},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 4},
  pages={
          1583-92
        }
}
Interferons are cytokines with potent antiviral and antiproliferative activities. We report that although a transient exposure to beta-interferon induces a reversible cell cycle arrest, a sustained treatment triggers a p53-dependent senescence program. Beta-interferon switched on p53 in two steps. First, it induced the acetylation of p53 at lysine 320 and its dephosphorylation at serine 392 but not p53 activity. Later on, it triggered a DNA signaling pathway, the phosphorylation of p53 at… CONTINUE READING

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