DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.

@article{Kondo2013DNADS,
  title={DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.},
  author={Takeshi Kondo and Junya Kobayashi and Tatsuya Saitoh and Kenta Maruyama and Ken J Ishii and Glen N Barber and Kenshi Komatsu and Shizuo Akira and Taro Kawai},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 8},
  pages={2969-74}
}
Double-stranded DNA (dsDNA) derived from pathogen- or host-damaged cells triggers innate immune responses when exposed to cytoplasm. However, the machinery underlying the primary recognition of intracellular dsDNA is obscure. Here we show that the DNA damage sensor, meiotic recombination 11 homolog A (MRE11), serves as a cytosolic sensor for dsDNA. Cells with a mutation of MRE11 gene derived from a patient with ataxia-telangiectasia-like disorder, and cells in which Mre11 was knocked down, had… CONTINUE READING
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