DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cells.

@article{Ma2014DNADR,
  title={DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cells.},
  author={Zhengwei Ma and Qingqing Wei and Guie Dong and Yuqing Huo and Zheng Dong},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1842 7},
  pages={1088-96}
}
Renal ischemia-reperfusion leads to acute kidney injury (AKI) that is characterized pathologically by tubular damage and cell death, followed by tubular repair, atrophy and interstitial fibrosis. Recent work suggested the possible presence of DNA damage response (DDR) in AKI. However, the evidence is sketchy and the role and regulation of DDR in ischemic AKI remain elusive. In this study, we demonstrated the induction of phosphorylation of ATM, H2AX, Chk2 and p53 during renal ischemia… CONTINUE READING
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