DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.

@article{Birch2015DNADR,
  title={DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.},
  author={Jodie Birch and Rhys K. Anderson and Clara Correia-Melo and Diana Jurk and Graeme Hewitt and Francisco Madeira Marques and Nicola J. Green and Elizabeth J Moisey and Mark A Birrell and Maria G Belvisi and Fiona A. Black and John T. Taylor and A. J. Fisher and Anthony De Soyza and Jo{\~a}o F. Passos},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2015},
  volume={309 10},
  pages={L1124-37}
}
Cellular senescence has been associated with the structural and functional decline observed during physiological lung aging and in chronic obstructive pulmonary disease (COPD). Airway epithelial cells are the first line of defense in the lungs and are important to COPD pathogenesis. However, the mechanisms underlying airway epithelial cell senescence, and… CONTINUE READING