DNA damage response at functional and dysfunctional telomeres.

  title={DNA damage response at functional and dysfunctional telomeres.},
  author={Maria Pia Longhese},
  journal={Genes & development},
  volume={22 2},
The ends of eukaryotic chromosomes have long been defined as structures that must avoid being detected as DNA breaks. They are protected from checkpoints, homologous recombination, end-to-end fusions, or other events that normally promote repair of intrachromosomal DNA breaks. This differentiation is thought to be the consequence of a unique organization of chromosomal ends into specialized nucleoprotein complexes called telomeres. However, it is becoming increasingly clear that proteins… CONTINUE READING