DNA damage response at functional and dysfunctional telomeres.

@article{Longhese2008DNADR,
  title={DNA damage response at functional and dysfunctional telomeres.},
  author={Maria Pia Longhese},
  journal={Genes & development},
  year={2008},
  volume={22 2},
  pages={125-40}
}
The ends of eukaryotic chromosomes have long been defined as structures that must avoid being detected as DNA breaks. They are protected from checkpoints, homologous recombination, end-to-end fusions, or other events that normally promote repair of intrachromosomal DNA breaks. This differentiation is thought to be the consequence of a unique organization of chromosomal ends into specialized nucleoprotein complexes called telomeres. However, it is becoming increasingly clear that proteins… CONTINUE READING