DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

  title={DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis},
  author={J. B{\'a}rtkov{\'a} and Z. Hořej{\vs}{\'i} and K. Koed and A. Kr{\"a}mer and F. Tort and K. Zieger and P. Guldberg and M. Sehested and Jahn M. Nesland and C. Lukas and T. {\O}rntoft and J. Lukas and J. Bartek},
  • J. Bártková, Z. Hořejší, +10 authors J. Bartek
  • Published 2005
  • Biology, Medicine
  • Nature
  • During the evolution of cancer, the incipient tumour experiences ‘oncogenic stress’, which evokes a counter-response to eliminate such hazardous cells. [...] Key Result Similar checkpoint responses were induced in cultured cells upon expression of different oncogenes that deregulate DNA replication. Together with genetic analyses, including a genome-wide assessment of allelic imbalances, our data indicate that early in tumorigenesis (before genomic instability and malignant conversion), human cells activate an…Expand Abstract
    DNA damage signalling guards against activated oncogenes and tumour progression
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