DNA damage response and cellular senescence in tissues of aging mice.

Abstract

The impact of cellular senescence onto aging of organisms is not fully clear, not at least because of the scarcity of reliable data on the mere frequency of senescent cells in aging tissues. Activation of a DNA damage response including formation of DNA damage foci containing activated H2A.X (gamma-H2A.X) at either uncapped telomeres or persistent DNA… (More)
DOI: 10.1111/j.1474-9726.2009.00481.x

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