DNA damage response--a double-edged sword in cancer prevention and cancer therapy.

  title={DNA damage response--a double-edged sword in cancer prevention and cancer therapy.},
  author={Hui Tian and Zhen Gao and Huizhong Li and Baofu Zhang and Gang Sam Wang and Qing Zhang and Dongsheng Pei and Junnian Zheng},
  journal={Cancer letters},
  volume={358 1},
Genomic stability depends on an efficient DNA damage repair system to keep the chromosomes intact. Unrepaired DNA damage not only causes cell cycle arrest, apoptosis, but also accumulates genome mutations. DNA damage response (DDR) exhibits a critical function on the protection against human cancer, as indicated by the high predisposition to cancer of individuals with germ-line mutations in DDR genes. However, a defective DNA repair is liked intimately with the unchecked proliferation and the… CONTINUE READING
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