DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression

@article{Carlessi2009DNAdamageRS,
  title={DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression},
  author={Luigi Carlessi and Lidia De Filippis and Daniele Lecis and Angelo L. Vescovi and Domenico Delia},
  journal={Cell Death and Differentiation},
  year={2009},
  volume={16},
  pages={795-806}
}
Ataxia-telangiectasia (A-T) is a neurodegenerative disorder caused by defects in the ATM kinase, a component of the DNA-damage response (DDR). Here, we employed an immortalized human neural stem-cell line (ihNSC) capable of differentiating in vitro into neurons, oligodendrocytes and astrocytes to assess the ATM-dependent response and outcome of ATM ablation. The time-dependent differentiation of ihNSC was accompanied by an upregulation of ATM and DNA-PK, sharp downregulation of ATR and Chk1… CONTINUE READING
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