DNA damage preceding dopamine neuron degeneration in A53T human α-synuclein transgenic mice.

@article{Wang2016DNADP,
  title={DNA damage preceding dopamine neuron degeneration in A53T human α-synuclein transgenic mice.},
  author={Degui Wang and Tianyu Yu and Yongqiang Liu and Jun Biao Yan and Yingli Guo and Yuhong Jing and Xuguang Yang and Yanfeng Song and Yingxia Tian},
  journal={Biochemical and biophysical research communications},
  year={2016},
  volume={481 1-2},
  pages={104-110}
}
Defective DNA repair has been linked with age-associated neurodegenerative disorders. Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by genetic and environmental factors. Whether damages to nuclear DNA contribute to neurodegeneration of PD still remain obscure. in this study we aim to explore whether nuclear DNA damage induce… CONTINUE READING