DNA damage-inducing agents elicit γ-secretase activation mediated by oxidative stress

@article{Jin2008DNADA,
  title={DNA damage-inducing agents elicit γ-secretase activation mediated by oxidative stress},
  author={Seok Min Jin and Hyung Jun Cho and Eun Sun Jung and M-Y Shim and Inhee Mook-jung},
  journal={Cell Death and Differentiation},
  year={2008},
  volume={15},
  pages={1375-1384}
}
According to the amyloid cascade hypothesis, Alzheimer’s disease is the consequence of neuronal cell death induced by β-amyloid (Aβ), which accumulates by abnormal clearance or production. On the other hand, recent studies have shown cell death-induced alteration in amyloid precursor protein (APP) processing, suggesting potential mutual interactions between APP processing and cell death. We have shown previously that the cell death caused by DNA damage-inducing agents (DDIAs) facilitated… CONTINUE READING