DNA damage induces phosphorylation of the amino terminus of p53.

  title={DNA damage induces phosphorylation of the amino terminus of p53.},
  author={Janet D Siliciano and Christine E. Canman and Yoichi Taya and Kazuyasu Sakaguchi and Ettore Appella and Michael B. Kastan},
  journal={Genes & development},
  volume={11 24},
Data are presented demonstrating that DNA damage leads to specific post-translational modifications of p53 protein. Using two-dimensional peptide mapping of in vivo radiolabeled p53 tryptic phosphopeptides, recombinant truncated p53 protein, and synthetic p53 tryptic peptides, a unique p53 phosphopeptide was identified after exposure of ML-1 cells to ionizing irradiation. This peptide represents the first 24 amino acids of p53 and contains three phosphorylated serine residues. A specific p53… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
282 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 282 extracted citations

Similar Papers

Loading similar papers…