DNA damage induces p53-dependent BRCA1 nuclear export.


The tumor suppressor gene BRCA1 plays an important role in the response to DNA damage. BRCA1 function is regulated by a variety of mechanisms including transcriptional control, phosphorylation, and protein-protein interactions. Recent studies have shown that BRCA1 is a nuclear-cytoplasmic shuttle protein. Its subcellular localization is controlled by a… (More)


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@article{Feng2004DNADI, title={DNA damage induces p53-dependent BRCA1 nuclear export.}, author={Zhihui Feng and Lisa Ann Kachnic and JunRan Zhang and Simon N. Powell and Fen Xia}, journal={The Journal of biological chemistry}, year={2004}, volume={279 27}, pages={28574-84} }