DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms.

  title={DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms.},
  author={Changgong Li and Lihong Chen and Jiandong Chen},
  journal={Molecular and cellular biology},
  volume={22 21},
The MDM2 homolog MDMX is an important regulator of p53 activity during embryonic development. MDMX inactivation in mice results in embryonic lethality in a p53-dependent fashion. The expression level of MDMX is not induced by DNA damage, and its role in stress response is unclear. We show here that ectopically expressed MDMX is mainly localized in the cytoplasm. DNA damage promotes nuclear translocation of MDMX in cells with or without p53. Coexpression of MDM2 or p53 is sufficient to induce… CONTINUE READING
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