DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae.

@article{Rowe2008DNADR,
  title={DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae.},
  author={Lori A. Rowe and Natalya P. Degtyareva and Paul W. Doetsch},
  journal={Free radical biology & medicine},
  year={2008},
  volume={45 8},
  pages={1167-77}
}
Cells are exposed to both endogenous and exogenous sources of reactive oxygen species (ROS). At high levels, ROS can lead to impaired physiological function through cellular damage of DNA, proteins, lipids, and other macromolecules, which can lead to certain human pathologies including cancers, neurodegenerative disorders, and cardiovascular disease, as well as aging. We have employed Saccharomyces cerevisiae as a model system to examine the levels and types of ROS that are produced in response… CONTINUE READING