DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.

Abstract

The Cdc25C phosphatase mediates cellular entry into mitosis. The cdc25C gene is a target for transcriptional downregulation by the tumor suppressor protein p53, and this repression can be shown to contribute to p53-dependent cell cycle arrest. Two independent mechanisms have been identified. One involves the direct binding of p53 to a site in the cdc25C… (More)

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@article{Clair2004DNADD, title={DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.}, author={Selvon St Clair and Luciana E. Giono and Shohreh Varmeh-Ziaie and Lois Resnick-Silverman and Wenjun Liu and Abhilash Padi and Jayasri Dastidar and Andrea DaCosta and Melissa Mattia and J J Manfredi}, journal={Molecular cell}, year={2004}, volume={16 5}, pages={725-36} }