DNA damage in rodent liver by 1,2-dichloroethane, a hepatocarcinogen.

The transcriptional and replicative activities of hepatic nuclei during DNA damage induced by 1,2-dichloroethane (DCE), a hepatocarcinogen, were examined. DNA damage was measured by DNA alkylation in rodents exposed to DCE. A time-dependent DNA damage in vivo and in vitro was observed. A significant inhibition of RNA synthesis was observed when… CONTINUE READING