DNA damage in diabetes: correlation with a clinical marker.

@article{Collins1998DNADI,
  title={DNA damage in diabetes: correlation with a clinical marker.},
  author={Andrew R Collins and Katar{\'i}na Ra{\vs}lov{\'a} and Martina Somorovsk{\'a} and Helena Petrovsk{\'a} and Adriana Ondrusova and Branislav Vohnout and R. F{\'a}bry and M{\'a}ria Du{\vs}insk{\'a}},
  journal={Free radical biology & medicine},
  year={1998},
  volume={25 3},
  pages={
          373-7
        }
}
Levels of DNA damage in groups of 10 patients with insulin-dependent diabetes mellitus and 10 matched controls were compared using the comet assay; DNA strand breaks, oxidized pyrimidines (endonuclease III-sensitive sites) and altered purines (sites sensitive to formamidopyrimidine glycosylase) were measured. Mean values of strand breaks and oxidized pyrimidines were significantly higher in diabetics. Strand breaks correlated with body mass index in the diabetic group. A strong correlation was… CONTINUE READING

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