DNA damage in cancer therapeutics: a boon or a curse?


Millions of DNA-damaging lesions occur every day in each cell of our bodies due to various stresses. The failure to detect and accurately repair these lesions can give rise to cells with high levels of endogenous DNA damage, deleterious mutations, or genomic aberrations. Such genomic instability can lead to the activation of specific signaling pathways… (More)
DOI: 10.1158/0008-5472.CAN-14-3247


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