DNA damage foci in mitosis are devoid of 53BP1.

  title={DNA damage foci in mitosis are devoid of 53BP1.},
  author={Glyn Nelson and Matthias T. Buhmann and Thomas von Zglinicki},
  journal={Cell cycle},
  volume={8 20},
Nuclear DNA damage foci indicate ongoing DNA damage response, which is the major inducer of cell cycle arrest, cellular senescence and apoptosis. 53BP1 is one central mediator of the DNA damage response and a component of active DNA damage foci. Using an AcGFP-53BP1c fluorescent fusion protein that quantitatively reports DNA damage, we show that the recruitment of 53BP1 into gammaH2A.X-containing DNA damage foci was inhibited at G(2)/M. This suggests a possible mechanism for cells to continue… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…