DNA damage enhancement from gold nanoparticles for clinical MV photon beams.

@article{Berbeco2012DNADE,
  title={DNA damage enhancement from gold nanoparticles for clinical MV photon beams.},
  author={Ross Berbeco and Houari Korideck and Wilfred F. Ngwa and Rajiv Kumar and Janki K. Patel and Srinivas Sridhar and Sarah A. Johnson and Brendan D. Price and Alec C. Kimmelman and G. Mike Makrigiorgos},
  journal={Radiation research},
  year={2012},
  volume={178 6},
  pages={604-8}
}
In this study, we quantify the relative damage enhancement due to the presence of gold nanoparticles (GNP) in vitro in a clinical 6 MV beam for various delivery parameters and depths. It is expected that depths and delivery modes that produce a larger proportions of low-energy photons will have a larger effect on the cell samples containing GNP. HeLa cells with and without 50 nm GNP were irradiated at depths of 1.5, 5, 10, 15 and 20 cm. Conventional beams with square aperture sizes 5, 10 and 15… CONTINUE READING