DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions.

@article{Fordyce2010DNADD,
  title={DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions.},
  author={Colleen Augusta Fordyce and Tim B Fessenden and Curtis R. Pickering and Jason Jung and Veena Singla and Hal K. Berman and Thea D. Tlsty},
  journal={Cancer prevention research},
  year={2010},
  volume={3 2},
  pages={190-201}
}
Cyclooxygenase-2 (COX-2) catalyzes the rate-limiting step in the synthesis of prostaglandins. Its overexpression induces numerous tumor-promoting phenotypes and is associated with cancer metastasis and poor clinical outcome. Although COX-2 inhibitors are promising chemotherapeutic and chemopreventative agents for cancer, the risk of significant cardiovascular and gastrointestinal complications currently outweighs their potential benefits. Systemic complications of COX-2 inhibition could be… CONTINUE READING

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