DNA damage checkpoints in stem cells, ageing and cancer

@article{Sperka2012DNADC,
  title={DNA damage checkpoints in stem cells, ageing and cancer},
  author={Tobias Sperka and Jianwei Wang and Karl Lenhard Rudolph},
  journal={Nature Reviews Molecular Cell Biology},
  year={2012},
  volume={13},
  pages={579-590}
}
DNA damage induces cell-intrinsic checkpoints, including p53 and retinoblastoma (RB), as well as upstream regulators (exonuclease 1 (EXO1), ataxia telangiectasia mutated (ATM), ATR, p16INK4a and p19ARF) and downstream targets (p21, PUMA (p53 upregulated modulator of apoptosis) and sestrins). Clearance of damaged cells by cell-intrinsic checkpoints suppresses carcinogenesis but as a downside may impair stem cell and tissue maintenance during ageing. Modulating the activity of DNA damage… CONTINUE READING
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