DNA damage checkpoints in stem cells, ageing and cancer

  title={DNA damage checkpoints in stem cells, ageing and cancer},
  author={Tobias Sperka and Jianwei Wang and Karl Lenhard Rudolph},
  journal={Nature Reviews Molecular Cell Biology},
DNA damage induces cell-intrinsic checkpoints, including p53 and retinoblastoma (RB), as well as upstream regulators (exonuclease 1 (EXO1), ataxia telangiectasia mutated (ATM), ATR, p16INK4a and p19ARF) and downstream targets (p21, PUMA (p53 upregulated modulator of apoptosis) and sestrins). Clearance of damaged cells by cell-intrinsic checkpoints suppresses carcinogenesis but as a downside may impair stem cell and tissue maintenance during ageing. Modulating the activity of DNA damage… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS