DNA damage caused by reactive oxygen species originating from a copper-dependent oxidation of the 2-hydroxy catechol of estradiol.

@article{Li1994DNADC,
  title={DNA damage caused by reactive oxygen species originating from a copper-dependent oxidation of the 2-hydroxy catechol of estradiol.},
  author={Yun Li and Michael A. Trush and James D. Yager},
  journal={Carcinogenesis},
  year={1994},
  volume={15 7},
  pages={1421-7}
}
It has previously been proposed that redox cycling between catechol estrogens and their quinones, mediated by cytochrome P450, could lead to the generation of free radicals that would subsequently cause oxidative damage to DNA and proteins that might have a role in hormonal carcinogenesis. Alternative, non-enzymatic mechanisms involving copper have been shown to participate in the oxidation of various chemicals through processes that also result in the appearance of reactive oxygen species and… CONTINUE READING

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