DNA damage by reactive species: Mechanisms, mutation and repair

  title={DNA damage by reactive species: Mechanisms, mutation and repair},
  author={N. Jena},
  journal={Journal of Biosciences},
  • N. Jena
  • Published 2012
  • Biology, Medicine
  • Journal of Biosciences
  • DNA is continuously attacked by reactive species that can affect its structure and function severely. Structural modifications to DNA mainly arise from modifications in its bases that primarily occur due to their exposure to different reactive species. Apart from this, DNA strand break, inter- and intra-strand crosslinks and DNA–protein crosslinks can also affect the structure of DNA significantly. These structural modifications are involved in mutation, cancer and many other diseases. As it… CONTINUE READING
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