DNA damage by reactive species: Mechanisms, mutation and repair

@article{Jena2012DNADB,
  title={DNA damage by reactive species: Mechanisms, mutation and repair},
  author={Nihar Ranjan Jena},
  journal={Journal of Biosciences},
  year={2012},
  volume={37},
  pages={503-517}
}
  • N. R. Jena
  • Published 26 June 2012
  • Biology, Medicine
  • Journal of Biosciences
DNA is continuously attacked by reactive species that can affect its structure and function severely. Structural modifications to DNA mainly arise from modifications in its bases that primarily occur due to their exposure to different reactive species. Apart from this, DNA strand break, inter- and intra-strand crosslinks and DNA–protein crosslinks can also affect the structure of DNA significantly. These structural modifications are involved in mutation, cancer and many other diseases. As it… 
View on Springer
ncbi.nlm.nih.gov
274 Citations
Highly Influential Citations
7
Background Citations
88

274 Citations

Citation Type

Citation Type

Formation of DNA Lesions, its Prevention and Repair
The present review discusses three important aspects which are intimately related to human health at the molecular level. The first aspect is the formation of DNA lesions caused due to the reactions…
How Do Yeast and Other Fungi Recognize and Respond to Genome Perturbations
TLDR
Maintaining a stable genome is a complicated task, even without any external problems such as genotoxic agents, irradiation, or any other harmful treatment to which cells are exposed in their environment.
Glutathione Directly Intercepts DNA Radicals to Inhibit Oxidative DNA-Protein Crosslinking Induced by the 1-electron Oxidation of Guanine.
TLDR
Results show that another important task for glutathione may be to directly intercept DNA radicals before permanent DNA damage can occur, and suggest a reduction process that is fast relative to the measurement.
DNA damage tolerance: a double-edged sword guarding the genome.
TLDR
The replication stress induced DNA damage-signaling cascade, the stabilization and rescue of stalled replication forks by the DDT pathway and the effect of theDDT pathway on cancer are discussed.
The emerging role of epigenetic modifiers in repair of DNA damage associated with chronic inflammatory diseases.
TLDR
Chronic inflammation may induce sustained DNA damage and DNA damage responses that result in transient covalent chromatin modifications becoming mitotically stable epigenetic alterations, which will allow us to develop pharmaceutical strategies to prevent or treat chronic inflammation-induced cancer.
ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses
TLDR
The current state of knowledge regarding ATM-dependent chromatin remodelling and epigenomic alterations that are required to maintain genomic integrity in the presence of DNA double-strand breaks and/or oxidative stress are reviewed.
Mutation Spectrum Induced by 8-Bromoguanine, a Base Damaged by Reactive Brominating Species, in Human Cells
TLDR
It is suggested that 8BrG induces some types of mutations, chiefly a G → T mutation, in human cells, and some DNA glycosylases are involved in the repair of 8 BrG.
Evidence for DNA Damage as a Biological Link Between Diabetes and Cancer
TLDR
This review highlights the interrelationships amongst diabetes, DNA damage, DNA mutation and carcinogenesis, which suggests that DNA damage can be a biological link between diabetes and cancer.
Oxidized extracellular DNA as a stress signal that may modify response to anticancer therapy.
TLDR
It seems that tumor cells are more sensitive to oxidized DNA-dependent DNA damage, while developing pronounced adaptive response, which may suggest that in chemotherapy or irradiation-treated human body, the release of oxidizedDNA from dying cancer cells may give a boost to remaining malignant cells by augmenting their survival and stress resistance.
Specific Recognition of Single Nucleotide by Alkylating Oligonucleotides and Sensing of 8-Oxoguanine
Gene expression is regulated by hierarchical mechanisms, for which not only the sequence but also the special structure of DNA and RNA play a vital role. This sophisticated systems also feature…
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 154 REFERENCES
Formation of ring-opened and rearranged products of guanine: mechanisms and biological significance.
TLDR
The main aim of this review is to provide a comprehensive overview of various possible reactions and the mechanisms involved, after which ring-opened and rearranged products of guanine would be formed in DNA.
Bulky DNA lesions induced by reactive oxygen species.
  • Yinsheng Wang
  • Chemistry, Medicine
    Chemical research in toxicology
  • 2008
TLDR
Biochemical studies demonstrated that ROS-induced single nucleobase lesions could markedly block DNA replication and transcription and that these lesions are repaired by the nucleotide excision repair (NER) pathway.
Chemistry and biology of DNA repair.
TLDR
The understanding of the genetic, biochemical, and structural basis of DNA repair and related processes has increased dramatically over the past decade, and this review summarizes the latest developments.
Molecular mechanism of nucleotide excision repair.
TLDR
The identification of two complementation groups (CS-A and CS-B) shows that at least two gene products are specifically needed for fast and efficient repair of transcribed strands, and suggests that transcription-coupled repair and/or the CS proteins have functions beyond NER.
Quantum theoretical study of molecular mechanisms of mutation and cancer - A review
TLDR
Three types of molecular events occur in biological media: DNA damage, DNA repair, and prevention of DNA damage by scavenging ROS and RNOS.
Role of oxygen radicals in DNA damage and cancer incidence
TLDR
The epidemiological trials together with in vitro experiments suggest that the optimal approach is to reduce endogenous and exogenous sources of oxidative stress, rather than increase intake of anti-oxidants.
Mechanisms of mutation by oxidative DNA damage: reduced fidelity of mammalian DNA polymerase beta.
TLDR
The oxidatively induced mutations fall into two categories: those apparently caused by direct miscoding of modified DNA and those associated with enhanced misincorporation at prexisting polymerase-specific hot spots, due to a conformational change in the DNA caused by oxidative modification and could be indicative of a novel mutagenic mechanism.
DNA Damage and Mutation Caused by Vital Biomolecules, Water, Nitric Oxide, and Hypochlorous Acid
The incidence of cancer can be decreased by avoiding the intake of mutagens and carcinogens; however, cancer is also induced by endogenous factors. Water is the most essential substance for life, but…
Mutagenicity associated with O6-methylguanine-DNA damage and mechanism of nucleotide flipping by AGT during repair.
TLDR
All aspects of DNA damage and repair have been addressed here by employing high level density functional theory in gas phase and aqueous medium and it is found that the actual cause of O6MG mediated mutation may arise due to the fact that DNA polymerases incorporate thymine opposite to O 6MG, misreading the resulting O6 MG:T complex as an A:T base pair.
Base-excision repair of oxidative DNA damage
TLDR
The properties of other guanine oxidation products and the associated DNA glycosylases that remove them are now also being revealed.
...
1
2
3
4
5
...