DNA damage and susceptibility to oxidative damage in lymphocytes: effects of carotenoids in vitro and in vivo.

@article{Astley2004DNADA,
  title={DNA damage and susceptibility to oxidative damage in lymphocytes: effects of carotenoids in vitro and in vivo.},
  author={Si{\^a}n B. Astley and David A. Hughes and Anthony J A Wright and Ruan M. Elliott and Susan Southon},
  journal={The British journal of nutrition},
  year={2004},
  volume={91 1},
  pages={53-61}
}
Reports on the effects of carotenoids are conflicting. The present paper examines similarities and differences from contiguous studies in vitro and in vivo. Single-cell gel electrophoresis was used to measure the frequency of single-strand breaks (SSB) in the cell line MOLT-17 (as a model system) and human peripheral blood lymphocytes (PBL). MOLT-17 cells were supplemented with beta-carotene, lutein or lycopene at a range of concentrations (0.00-8.00 micromol/l) using a liposome delivery method… CONTINUE READING