DNA damage and repair in gastric cancer--a correlation with the hOGG1 and RAD51 genes polymorphisms.

@article{Poplawski2006DNADA,
  title={DNA damage and repair in gastric cancer--a correlation with the hOGG1 and RAD51 genes polymorphisms.},
  author={Tomasz R. Poplawski and Michal Arabski and Dorota Kozirowska and Maria Blasinska-Morawiec and Zbigniew Morawiec and Alina Morawiec-Bajda and Grażyna Klupińska and Arkadiusz Jeziorski and Jan Chojnacki and Janusz Blasiak},
  journal={Mutation research},
  year={2006},
  volume={601 1-2},
  pages={83-91}
}
The cell's susceptibility to mutagens and its ability to repair DNA lesions are important for cancer induction, promotion and progression. Both the mutagens' sensitivity and the efficacy of DNA repair may be affected by variation in several genes, including DNA repair genes. The hOGG1 gene encodes glycosylase of base excision repair and RAD51 specifies a key protein in homologues recombination repair. Both can be involved in the repair of oxidative DNA lesions, which can contribute to stomach… CONTINUE READING

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