DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles.

@article{Asharani2010DNADA,
  title={DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles.},
  author={P. V. Asharani and Ng Xinyi and Manoor Prakash Hande and Suresh Valiyaveettil},
  journal={Nanomedicine},
  year={2010},
  volume={5 1},
  pages={51-64}
}
AIM Platinum-based therapeutic agents are widely used in medicine. Thus, a thorough understanding of their mechanism of action in cells is warranted. This study investigates the uptake and bioactivity (e.g., cytotoxicity, genotoxicity and protein expression) of platinum nanoparticles (Pt-NPs, approximately 5-8 nm in size) in human cells. MATERIALS & METHODS Pt-NPs capped with polyvinyl alcohol were synthesized, characterized and incubated with human cells. Uptake and the biological properties… CONTINUE READING

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