DNA damage and micronuclei induced in rat and human kidney cells by six chemicals carcinogenic to the rat kidney.

@article{Robbiano2004DNADA,
  title={DNA damage and micronuclei induced in rat and human kidney cells by six chemicals carcinogenic to the rat kidney.},
  author={Luigi Robbiano and Debora Baroni and Roberto Carrozzino and Eugenio Mereto and Giovanni Brambilla},
  journal={Toxicology},
  year={2004},
  volume={204 2-3},
  pages={187-95}
}
Six chemicals, known to induce kidney tumors in rats, were examined for their ability to induce DNA fragmentation and formation of micronuclei in primary cultures of rat and human kidney cells, and in the kidney of intact rats. Significant dose-dependent increases in the frequency of DNA single-strand breaks and alkali-labile sites, as measured by the Comet assay, and in micronuclei frequency, were obtained in primary kidney cells from both male rats and humans of both genders with the… CONTINUE READING

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