DNA damage and cell cycle regulation of ribonucleotide reductase.

  title={DNA damage and cell cycle regulation of ribonucleotide reductase.},
  author={Stephen J Elledge and Zheng Zhou and Judith B Allen and Tony A. Navas},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={15 5},
Ribonucleotide reductase (RNR) catalyzes the rate limiting step in the production of deoxyribonucleotides needed for DNA synthesis. In addition to the well documented allosteric regulation, the synthesis of the enzyme is also tightly regulated at the level of transcription. mRNAs for both subunits are cell cycle regulated and inducible by DNA damage in all organisms examined, including E. coli, S. cerevisiae and H. sapiens. This DNA damage regulation is thought to provide a metabolic state that… CONTINUE READING