DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells

@article{Trapani2003DNADA,
  title={DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells},
  author={Valentina Trapani and Vyomesh S. Patel and C-O Leong and Henry P. Ciolino and Grace Chao Yeh and Curtis D. Hose and Jane B. Trepel and Malcolm F. G. Stevens and Edward A. Sausville and Andrea Irene Loaiza-P{\'e}rez},
  journal={British Journal of Cancer},
  year={2003},
  volume={88},
  pages={599 - 605}
}
The fluorinated benzothiazole analogue 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is a novel agent with potent and selective antitumour properties and, in the form of its L-lysylamide prodrug Phortress (NSC 710305), is a current candidate for early phase clinical studies. Previous findings have indicated that cytochrome P450 1A1 (CYP1A1) may play a role in the antitumour activity of molecules in the benzothiazole series including the nonfluorinated parent compound 2… CONTINUE READING

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