DNA damage and apoptosis in hydrogen peroxide-exposed Jurkat cells: bolus addition versus continuous generation of H(2)O(2).

@article{Barbouti2002DNADA,
  title={DNA damage and apoptosis in hydrogen peroxide-exposed Jurkat cells: bolus addition versus continuous generation of H(2)O(2).},
  author={Alexandra Barbouti and P T Doulias and Lambros Nousis and Margarita Tenopoulou and Dimitrios Galaris},
  journal={Free radical biology & medicine},
  year={2002},
  volume={33 5},
  pages={691-702}
}
Aspects of the molecular mechanism(s) of hydrogen peroxide-induced DNA damage and cell death were studied in the present investigation. Jurkat T-cells in culture were exposed either to low rates of continuously generated H(2)O(2) by the action of glucose oxidase or to a bolus addition of the same agent. In the first case, steady state conditions were prevailing, while in the latter, H(2)O(2) was removed by the cellular defense systems following first order kinetics. By using single-cell gel… CONTINUE READING

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