DNA damage and anti-tumor activity induced by Zn, Ag and Co containing meso- tetra(4-N-oxyethylpyridyl)porphyrins in vivo

@article{Karapetyan2010DNADA,
  title={DNA damage and anti-tumor activity induced by Zn, Ag and Co containing meso- tetra(4-N-oxyethylpyridyl)porphyrins in vivo},
  author={Nelli H. Karapetyan and Lusya V. Torosyan and Gayane V. Ananyan and Rafael Muradyan},
  journal={Journal of Porphyrins and Phthalocyanines},
  year={2010},
  volume={14},
  pages={349-353}
}
In the present study, the activity of the new water-soluble cationic meso-tetra(4-N-oxyethylpyridyl)porphyrin and its Zn, Ag and Co metal derivatives as anti-tumor agents was explored. The tumor was induced by 7,12-dimethylbenz[a]antracene (DMBA) on rats of Wistar strain. The levels of DNA damage induced by porphyrins T4OEPyP, AgT4OEPyP, ZnT4OEPyP and CoT4OEPyP in tumor tissue were analyzed. Thermodynamic parameters of DNA were investigated by thermal melting method and differential scanning… 
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