DNA damage after acute exposure of mice skin to physiological doses of UVB and UVA light

  title={DNA damage after acute exposure of mice skin to physiological doses of UVB and UVA light},
  author={Alena Rajnochov{\'a} Svobodov{\'a} and A. Galand{\'a}kov{\'a} and Jarmila {\vS}iansk{\'a} and Dalibor Dole{\vz}al and R. Lichnovska and J. Ulrichov{\'a} and J. Vost{\'a}lov{\'a}},
  journal={Archives of Dermatological Research},
  • Alena Rajnochová Svobodová, A. Galandáková, +4 authors J. Vostálová
  • Published 2012
  • Medicine, Biology
  • Archives of Dermatological Research
  • Solar ultraviolet (UV) radiation is an important risk factor in skin carcinogenesis. This has been attributed mainly to the UVB waveband because the high-energetic photons are capable of interacting with DNA and inducing DNA damage. Recently, UVA light has also gained increasing interest in relation to DNA alteration. Although UVA photons are less energetic than UVB, they comprise a major fraction of sunlight UV radiation and penetrate deep into the skin. The study was carried out to compare… CONTINUE READING
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    • 119
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    The spectral dependence for UVA-induced cumulative damage in human skin.
    • 106