DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

@article{Bakkenist2003DNADA,
  title={DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation},
  author={C. Bakkenist and M. Kastan},
  journal={Nature},
  year={2003},
  volume={421},
  pages={499-506}
}
  • C. Bakkenist, M. Kastan
  • Published 2003
  • Chemistry, Medicine
  • Nature
  • The ATM protein kinase, mutations of which are associated with the human disease ataxia–telangiectasia, mediates responses to ionizing radiation in mammalian cells. Here we show that ATM is held inactive in unirradiated cells as a dimer or higher-order multimer, with the kinase domain bound to a region surrounding serine 1981 that is contained within the previously described ‘FAT’ domain. Cellular irradiation induces rapid intermolecular autophosphorylation of serine 1981 that causes dimer… CONTINUE READING

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