DNA damage‐dependent mechanisms of ageing and disease in the macro‐ and microvasculature

  title={DNA damage‐dependent mechanisms of ageing and disease in the macro‐ and microvasculature},
  author={Aarti V. Shah and M. Bennett},
  journal={European Journal of Pharmacology},
  • Aarti V. Shah, M. Bennett
  • Published 2017
  • Medicine
  • European Journal of Pharmacology
  • Abstract A decline in the function of the macro‐ and micro‐vasculature occurs with ageing. DNA damage also accumulates with ageing, and thus DNA damage and repair have important roles in physiological ageing. Considerable evidence also supports a crucial role for DNA damage in the development and progression of macrovascular disease such as atherosclerosis. These findings support the concept that prolonged exposure to risk factors is a major stimulus for DNA damage within the vasculature, in… CONTINUE READING
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