DNA damage: ubiquitin marks the spot

  title={DNA damage: ubiquitin marks the spot},
  author={Eric J Bennett and J Wade Harper},
  journal={Nature Structural &Molecular Biology},
VOLUME 15 NUMBER 1 JANUARY 2008 NATURE STRUCTURAL & MOLECULAR BIOLOGY Genomic integrity is central to organismal homeostasis. Mutations occurring in critical genes can promote developmental defects and diseases such as cancer. Our genomes are constantly under siege by environmental factors such as radiation and byproducts of cellular metabolism such as reactive oxygen species that can damage DNA. Such insults unleash a network of DNA repair processes referred to as the DNA damage response (DDR… CONTINUE READING


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