DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis

@article{Xu2006DNADA,
  title={DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis},
  author={Yang Xu},
  journal={Nature Reviews Immunology},
  year={2006},
  volume={6},
  pages={261-270}
}
Chromosome breakage is frequently associated with viral infection and cellular transformation, but it is also required for two processes that are crucial for the development and function of adaptive immunity: V(D)J recombination and class-switch recombination. The cellular responses that result from this type of DNA damage, which are mostly activated by the protein kinase ataxia-telangiectasia mutated (ATM), lead to cell-cycle arrest at several checkpoints and efficient DNA repair. This Review… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
34 Citations
118 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 118 references

Functional interaction of H 2 AX , NBS 1 , and p 53 in ATMdependent DNA damage responses and tumor suppression

  • J. Kang
  • Mol . Cell . Biol .
  • 2005

NKG 2 D function protects the host from tumor initiation

  • M. J. Smyth
  • J . Exp . Med .
  • 2005

Similar Papers

Loading similar papers…