DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas.

@article{Erickson1980DNACA,
  title={DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas.},
  author={Leonard C. Erickson and Matthews O. Bradley and Jonathan M. Ducore and R A Ewig and Kurt W. Kohn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 1},
  pages={467-71}
}
Normal (IMR-90) and simian virus 40-transformed (VA-13) human embryo cells were treated with antitumor nitrosoureas, and the effects on cell viability and cell DNA were compared. All six nitrosoureas tested were more toxic to VA-13 cells than to IMR-90 cells as measured by decrease in cell proliferation or in colony formation. The nitrosoureas capable of generating alkylisocyanates produced a smaller difference between the cell types than did derivatives lacking this capacity. DNA damage was… CONTINUE READING