DNA copy-number control through inhibition of replication fork progression.

Abstract

Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is regulated primarily at the level of initiation and is under strict cell-cycle regulation. Importantly, DNA replication is highly influenced by… (More)
DOI: 10.1016/j.celrep.2014.10.005

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