DNA copy number alterations and expression of relevant genes in triple-negative breast cancer.

@article{Han2008DNACN,
  title={DNA copy number alterations and expression of relevant genes in triple-negative breast cancer.},
  author={Wonshik Han and Eun-Mi Jung and Jihyoung Cho and Jong Won Lee and Ki-Tae Hwang and Song-Ju Yang and Jason Jongho Kang and Ji-Yeon Bae and Yoon Kyung Jeon and In-ae Park and Monica Nicolau and Stefanie S. Jeffrey and Dong-Young Noh},
  journal={Genes, chromosomes & cancer},
  year={2008},
  volume={47 6},
  pages={490-9}
}
Triple-negative breast cancer (TNBC) is defined by a lack of expression of estrogen, progesterone, and HER2 receptors, and genetically most of them fall into the basal subgroup of breast cancer. The important issue of TNBC is poorer clinical outcome and absence of effective targeted therapy. In this study, we sought to identify DNA copy number alterations and expression of relevant genes characteristic of TNBC to discover potential therapeutic targets. Frozen tissues from 114 breast cancers… CONTINUE READING

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