DNA content proportionality and persistence of radiation-induced chromosomal aberrations studied by FISH.

Chromosome aberrations induced by radiation have been used for the purpose of dosimetry for a long time. Translocations are especially useful for retrospective dosimetry, since they are assumed to be stable. The method of chromosome painting (FISH) has facilitated objective scoring of aberrations considerably. Translocation frequencies, obtained by FISH… CONTINUE READING