DNA conformations and their sequence preferences

  title={DNA conformations and their sequence preferences},
  author={Daniel Svozil and Jan Kalina and Marek Omelka and Bohdan Schneider},
  booktitle={Nucleic acids research},
The geometry of the phosphodiester backbone was analyzed for 7739 dinucleotides from 447 selected crystal structures of naked and complexed DNA. Ten torsion angles of a near-dinucleotide unit have been studied by combining Fourier averaging and clustering. Besides the known variants of the A-, B- and Z-DNA forms, we have also identified combined A + B backbone-deformed conformers, e.g. with alpha/gamma switches, and a few conformers with a syn orientation of bases occurring e.g. in G-quadruplex… CONTINUE READING