DNA condensation by the nucleocapsid protein of HIV-1: a mechanism ensuring DNA protection.

@article{Krishnamoorthy2003DNACB,
  title={DNA condensation by the nucleocapsid protein of HIV-1: a mechanism ensuring DNA protection.},
  author={Guruswamy Krishnamoorthy and B. Roques and J. -L. Darlix and Yves M{\'e}ly},
  journal={Nucleic acids research},
  year={2003},
  volume={31 18},
  pages={5425-32}
}
The nucleocapsid (NC) protein NCp7 of the immunodeficiency virus type 1 is a small basic protein with two zinc finger motifs. NCp7 has key roles in virus replication and structure, which rely on its interactions with nucleic acids. Although most interactions involve RNAs, binding to the viral DNA is thought to be of importance to achieve protection of the DNA against cellular nucleases and its integration into the host genome. We investigated the interaction of NCp7 with plasmid DNA as a model… CONTINUE READING
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