DNA compaction by the nuclear factor-Y.

  title={DNA compaction by the nuclear factor-Y.},
  author={Rosalinda Fiorella Guerra and Laura Imperadori and Roberto Mantovani and David Dunlap and Laura Finzi},
  journal={Biophysical journal},
  volume={93 1},
The nuclear factor-Y (NF-Y), a trimeric, CCAAT-binding transcriptional activator with histone-like subunits, was until recently considered a prototypical promoter transcription factor. However, recent in vivo chromatin immunoprecipitation assays associated with microarray methodologies (chromatin immunoprecipitation on chip experiments) have indicated that a large portion of target sites (40%-50%) are located outside of core promoters. We applied the tethered particle motion technique to the… CONTINUE READING